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N-(2-ferrocene-ethyl)maleimide: a new electroactive sulphydryl-specific reagent for cysteine-containing peptides and proteins.

Abstract:
We report the synthesis and application of a specific electroactive label, N-(2-ferrocene-ethyl)maleimide, which provides new redox properties to organic compounds and proteins possessing sulphydryl groups. Its reaction conditions with the cysteine-containing peptide, glutathione, and a terminal monooxygenase enzyme, cytochrome P450cam are presented. The labelled peptide and enzyme acquired reversible electrochemical properties due to the attached ferrocene moiety.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Role:
Author
Journal:
FEBS letters
Volume:
390
Issue:
2
Pages:
142-144
Publication date:
1996-07-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:62ea6334-ee18-40f5-92b9-60e78787369e
Source identifiers:
35948
Local pid:
pubs:35948

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