Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

Journal article

Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell interactions and transendothelial migration. We find that Cdc42 regulates β1 integrin expression at the transcriptional level via the transcription factor serum response factor (SRF). β1 integrin is the main target for Cdc42-mediating interaction of ca...

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Authors: Reymond, N; Im, J; Garg, R; Vega, F; Borda d'Agua, B

• Publication status: Published
• Journal: Journal of cell biology
• Volume: 199
• Issue: 4
• Pages: 653-668
• Publication date: 2012-11-01
• DOI: 10.1083/jcb.201205169
• EISSN: 1540-8140
• ISSN: 0021-9525
• Language: English
• Keywords: Animals; Cells, Cultured; Transcription, Genetic; Serum Response Factor; rac1 GTP-Binding Protein; Fibronectins; cdc42 GTP-Binding Protein; Gene Expression Regulation, Neoplastic; Cell Line, Tumor; Transendothelial and Transepithelial Migration; Mice, SCID; rhoA GTP-Binding Protein; Endothelial Cells; Protein Transport; Humans; Antigens, CD29; Cell Adhesion; Mice; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Transplantation