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Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

Abstract:

Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell interactions and transendothelial migration. We find that Cdc42 regulates β1 integrin expression at the transcriptional level via the transcription factor serum response factor (SRF). β1 integrin is the main target for Cdc42-mediating interaction of ca...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.201205169

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Journal:
Journal of cell biology More from this journal
Volume:
199
Issue:
4
Pages:
653-668
Publication date:
2012-11-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525

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