Journal article
Overexpression of ubiquitin-specific peptidase 15 in systemic sclerosis fibroblasts increases response to transforming growth factor β
- Abstract:
-
Objective Ubiquitination of proteins leads to their degradation by the proteasome, and is regulated by ubiquitin ligases and substrate-specific ubiquitin-specific peptidases (USPs). The ubiquitination process also plays important roles in the regulation of cell metabolism and cell cycle. Here, we found that the expression of several USPs is increased in SSc tenosynovial and skin biopsies, and we demonstrated that USP inhibition decreases TGF-β signalling in primary fibroblast... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Version of record, pdf, 779.3KB)
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- Publisher copy:
- 10.1093/rheumatology/key401
Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Rheumatology Journal website
- Volume:
- 58
- Issue:
- 4
- Pages:
- 708–718
- Publication date:
- 2019-01-03
- Acceptance date:
- 2018-11-03
- DOI:
- EISSN:
-
1462-0332
- ISSN:
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1462-0324
- Pmid:
-
30608617
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:960117
- UUID:
-
uuid:62dfb1e0-4da1-4d0e-a5c1-887e9e0aef0f
- Local pid:
- pubs:960117
- Source identifiers:
-
960117
- Deposit date:
- 2019-01-21
Terms of use
- Copyright holder:
- Galant et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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