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Acute administration of L-arginine does not improve arterial endothelial function in chronic renal failure.

Abstract:

BACKGROUND: Reduced activity of the nitric oxide (NO) pathway has been implicated in the endothelial dysfunction that occurs in patients with renal failure. NO is generated from L-arginine by NO synthase, and certain uremic toxins including asymmetrical dimethyl-L-arginine (ADMA), inhibit NO synthase and might contribute to endothelial dysfunction. We hypothesized that exogenous L-arginine might improve endothelial function in patients with renal failure by overcoming the effects of uremic to...

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Publication status:
Published

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Authors


Donald, AE More by this author
Kharbanda, R More by this author
Deanfield, JE More by this author
Woolfson, RG More by this author
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Journal:
Kidney international
Volume:
60
Issue:
6
Pages:
2318-2323
Publication date:
2001-12-05
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
URN:
uuid:62de484e-36f3-44b8-bfc0-034074200e46
Source identifiers:
105124
Local pid:
pubs:105124

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