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A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer.

Abstract:

PURPOSE: The aim of this study was to determine in patients with previously untreated advanced colorectal cancer the maximum tolerated dose (MTD) and safety profile of irinotecan in combination with capecitabine, to identify a recommended dose and to determine the response rate and time to disease progression. In addition, we aimed to explore the pharmacokinetic parameters of irinotecan and capecitabine when used in different sequences of administration, with irinotecan infusion either prior...

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Publication status:
Published

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Publisher copy:
10.1093/annonc/mdi227

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Journal:
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Volume:
16
Issue:
7
Pages:
1123-1132
Publication date:
2005-07-05
DOI:
EISSN:
1569-8041
ISSN:
0923-7534
URN:
uuid:62ddc9cb-bf84-42c2-90f4-27e1eeab97c3
Source identifiers:
236999
Local pid:
pubs:236999

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