- Abstract:
-
PURPOSE: The aim of this study was to determine in patients with previously untreated advanced colorectal cancer the maximum tolerated dose (MTD) and safety profile of irinotecan in combination with capecitabine, to identify a recommended dose and to determine the response rate and time to disease progression. In addition, we aimed to explore the pharmacokinetic parameters of irinotecan and capecitabine when used in different sequences of administration, with irinotecan infusion either prior...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/annonc/mdi227
-
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- Journal:
- Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
- Volume:
- 16
- Issue:
- 7
- Pages:
- 1123-1132
- Publication date:
- 2005-07-05
- DOI:
- EISSN:
-
1569-8041
- ISSN:
-
0923-7534
- URN:
-
uuid:62ddc9cb-bf84-42c2-90f4-27e1eeab97c3
- Source identifiers:
-
236999
- Local pid:
- pubs:236999
- Copyright date:
- 2005
Journal article
A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer.
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