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Journal article

Population pharmacokinetics of mefloquine given as a 3-day artesunate-mefloquine in patients with acute uncomplicated Plasmodium falciparum malaria in a multidrug-resistant area along the Thai-Myanmar border

Abstract:

Background

Low mefloquine exposure has been shown to contribute to treatment failure in patients with uncomplicated falciparum malaria following a 3-day artesunate–mefloquine combination. The present study aimed to develop a population pharmacokinetic model for mefloquine based on whole blood concentration–time profiles of this target population for further dose optimization.

Methods

A total of 129 Burmese patients aged above 15 years who presented with typical sy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-018-2466-3

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Name:
National Research Council of Thailand
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Name:
Office of Higher Education Commission of Thailand.
More from this funder
Name:
Center of Excellence in Pharmacology and Molecular Biology of Malaria
Publisher:
BioMed Central
Journal:
Malaria Journal More from this journal
Volume:
17
Issue:
1
Pages:
322
Publication date:
2018-09-03
Acceptance date:
2018-08-27
DOI:
ISSN:
1475-2875
Keywords:
Pubs id:
pubs:920697
UUID:
uuid:62db2da0-ea6f-4842-b462-95618b6bf724
Local pid:
pubs:920697
Source identifiers:
920697
Deposit date:
2018-11-15

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