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Population pharmacokinetics of mefloquine given as a 3-day artesunate-mefloquine in patients with acute uncomplicated Plasmodium falciparum malaria in a multidrug-resistant area along the Thai-Myanmar border

Abstract:

Background

Low mefloquine exposure has been shown to contribute to treatment failure in patients with uncomplicated falciparum malaria following a 3-day artesunate–mefloquine combination. The present study aimed to develop a population pharmacokinetic model for mefloquine based on whole blood concentration–time profiles of this target population for further dose optimization.

Methods

A total of 129 Burmese patients aged above 15 years who presented with typical sy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/s12936-018-2466-3

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
Center of Excellence in Pharmacology and Molecular Biology of Malaria More from this funder
National Research Council of Thailand More from this funder
Office of Higher Education Commission of Thailand. More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
17
Issue:
1
Pages:
322
Publication date:
2018-09-03
Acceptance date:
2018-08-27
DOI:
ISSN:
1475-2875
Pubs id:
pubs:920697
URN:
uri:62db2da0-ea6f-4842-b462-95618b6bf724
UUID:
uuid:62db2da0-ea6f-4842-b462-95618b6bf724
Local pid:
pubs:920697

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