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The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.

Abstract:

INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1) antagonist rimonabant can block the orexigenic effect of ghrelin. In this study, we have elucidated the mechanism of the putative ghrelin-cannabinoid interaction. METHODS: The effects of ghrelin and CB1 antagonist rimonabant in wild-type mi...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0001797

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Journal:
PloS one
Volume:
3
Issue:
3
Pages:
e1797
Publication date:
2008-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
138463
Language:
English
Keywords:
Pubs id:
pubs:138463
UUID:
uuid:62d98ccb-5268-4b13-8a5c-d1455e0f6aaa
Local pid:
pubs:138463
Deposit date:
2012-12-19

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