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Prisoners of war — host adaptation and its constraints on virus evolution

Abstract:

Recent discoveries of contemporary genotypes of hepatitis B virus and parvovirus B19 in ancient human remains demonstrate that little genetic change has occurred in these viruses over 4,500–6,000 years. Endogenous viral elements in host genomes provide separate evidence that viruses similar to many major contemporary groups circulated 100 million years ago or earlier. In this Opinion article, we argue that the extraordinary conservation of virus genome sequences is best explained by a niche-f...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41579-018-0120-2

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
St Hildas College
Publisher:
Springer Nature Publisher's website
Journal:
Nature Reviews Microbiology Journal website
Volume:
17
Pages:
321–328
Publication date:
2018-12-05
DOI:
EISSN:
1740-1534
ISSN:
1740-1526
Pubs id:
pubs:952107
URN:
uri:62d6a53e-5281-4f42-8483-87e86b9965a4
UUID:
uuid:62d6a53e-5281-4f42-8483-87e86b9965a4
Local pid:
pubs:952107
Language:
English

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