Journal article
Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56
- Abstract:
-
During mitosis, the formation of microtubule–kinetochore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1). MPS1 is recruited to unattached kinetochores where it phosphorylates KNL1, BUB1, and MAD1 to initiate the spindle assembly checkpoint. This arrests the cell cycle until all kinetochores have been stably captured by microtubules. MPS1 also contributes to the error correction process rectifying incorrect kinetochore attachments. MPS1 activity at kinetochor...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Cell Biology Journal website
- Volume:
- 218
- Issue:
- 10
- Pages:
- 3188–3199
- Publication date:
- 2019-09-11
- Acceptance date:
- 2019-08-06
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1046453
- UUID:
-
uuid:62d497e1-6af1-4d05-a5ff-b5f604d68405
- Local pid:
- pubs:1046453
- Source identifiers:
-
1046453
- Deposit date:
- 2019-09-12
Terms of use
- Copyright holder:
- Hayward et al.
- Copyright date:
- 2019
- Rights statement:
- © 2019 Hayward et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
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