Febrile infection-related epilepsy syndrome without detectable autoantibodies and response to immunotherapy: a case series and discussion of epileptogenesis in FIRES.

Journal article

Febrile infection-related epilepsy syndrome (FIRES) is a severe postinfectious epileptic encephalopathy in previously healthy children and has three phases: the initial phase with a simple febrile infection, a few days later the acute phase characterized by a peracute onset of highly recurrent seizures or refractory status epilepticus often with no more fever and generally without additional neurological features (the classical pure seizure phenotype), and last, the chronic phase with a drug-...

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Authors: van Baalen, A; Häusler, M; Plecko-Startinig, B; Strautmanis, J; Vlaho, S

• Publication status: Published
• Journal: Neuropediatrics
• Volume: 43
• Issue: 4
• Pages: 209-216
• Publication date: 2012-08-21
• DOI: 10.1055/s-0032-1323848
• EISSN: 1439-1899
• ISSN: 0174-304X
• Language: English
• Keywords: Child, Preschool; Retrospective Studies; Receptors, AMPA; Potassium Channels, Voltage-Gated; Humans; Membrane Proteins; Epilepsy; Transfection; Immunotherapy; Brain; Male; Proteins; Autoantibodies; HEK293 Cells; Diagnosis, Differential; Child; Prospective Studies; Encephalitis; Receptors, GABA-A; Nerve Tissue Proteins; Radioimmunoprecipitation Assay; Female; Receptors, N-Methyl-D-Aspartate; Magnetic Resonance Imaging