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Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors.

Abstract:

We studied the effects of the 5-HT2 receptor antagonists, ritanserin and ketanserin, on the sleep of healthy volunteers in order to clarify the role of 5-HT2A and 5-HT2C receptors in the regulation of slow wave sleep (SWS) in humans. Ritanserin, 5 mg, produced a substantially larger increase in SWS (51.4%) than either ketanserin, 20 mg (17.2%) or ketanserin, 40 mg (24.4%). Ritanserin has a significantly higher affinity than ketanserin for 5-HT2C receptor binding sites in the human brain and, ...

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Publication status:
Published

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Journal:
Neuropharmacology
Volume:
33
Issue:
3-4
Pages:
467-471
Publication date:
1994-01-01
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Source identifiers:
186007
Language:
English
Keywords:
Pubs id:
pubs:186007
UUID:
uuid:62ce4748-c3cc-4944-bcff-a5c8c70e5227
Local pid:
pubs:186007
Deposit date:
2012-12-19

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