It takes a PHD to read the histone code.

Journal article

The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.

Authors: Mellor, J

• Publication status: Published
• Journal: Cell
• Volume: 126
• Issue: 1
• Pages: 22-24
• Publication date: 2006-07-01
• DOI: 10.1016/j.cell.2006.06.028
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Plant Proteins; Models, Molecular; Chromatin; Histones; Repressor Proteins; Protein Structure, Tertiary; Gene Expression Regulation, Plant; Homeodomain Proteins