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Cardiac troponin T and troponin I in the general population: comparing and contrasting their genetic determinants and associations with outcomes

Abstract:

Background: There is great interest in widening the use of high-sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it is not clear whether cardiac troponin T (cTnT) and troponin I (cTnI) are equivalent measures of risk in this setting. We aimed to compare and contrast (1) the association of cTnT and cTnI with CVD and non-CVD outcomes, and (2) their determinants in a genome-wide association study.
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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/CIRCULATIONAHA.118.038529

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women's & Reproductive Health
Sub department:
Women's & Reproductive Health
Department:
Oxford, MSD, Womens & Reproductive Health
Role:
Author
Publisher:
Wolters Kluwer Health Publisher's website
Journal:
Circulation Journal website
Volume:
139
Issue:
24
Pages:
2754-2764
Publication date:
2019-04-24
Acceptance date:
2019-03-20
DOI:
ISSN:
0009-7322
Keywords:
Pubs id:
pubs:983595
UUID:
uuid:62ba3536-5840-4a64-b9a1-ce432aedb140
Local pid:
pubs:983595
Source identifiers:
983595
Deposit date:
2019-03-21

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