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Journal article

Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.

Abstract:

A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), of which CD4(+)Foxp3(+) cells are proven as essential to self-tolerance. Using transgenic B6.Foxp3(hCD2) mice to isolate and ablate Foxp3(+) T reg cells with an anti-hCD2 antibody, we show for the first time that CD4(+)Foxp3(+) cells are crucial for infectious tolerance induced by nonablative anti-T cell antibodies. In tolerant animals, Foxp3(+) T reg cells are constantly required to suppress eff...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20110767

Authors


Kendal, AR More by this author
Regateiro, FS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
The Journal of experimental medicine
Volume:
208
Issue:
10
Pages:
2043-2053
Publication date:
2011-09-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:62b7eb1f-5d52-470d-92c3-f9501f63adca
Source identifiers:
172124
Local pid:
pubs:172124

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