- Abstract:
-
A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), of which CD4(+)Foxp3(+) cells are proven as essential to self-tolerance. Using transgenic B6.Foxp3(hCD2) mice to isolate and ablate Foxp3(+) T reg cells with an anti-hCD2 antibody, we show for the first time that CD4(+)Foxp3(+) cells are crucial for infectious tolerance induced by nonablative anti-T cell antibodies. In tolerant animals, Foxp3(+) T reg cells are constantly required to suppress eff...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20110767
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 208
- Issue:
- 10
- Pages:
- 2043-2053
- Publication date:
- 2011-09-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:62b7eb1f-5d52-470d-92c3-f9501f63adca
- Source identifiers:
-
172124
- Local pid:
- pubs:172124
- Copyright date:
- 2011
Journal article
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
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