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Journal article

Compositional and functional differences in the human gut microbiome correlate with clinical outcome following infection with wild-type Salmonella enterica serovar Typhi

Abstract:

Insights into disease susceptibility as well as the efficacy of vaccines against typhoid and other enteric pathogens may be informed by better understanding the relationship between the effector immune response and the gut microbiota. In the present study, we characterized the composition (16S rRNA gene profiling) and function (RNA sequencing [RNA-seq]) of the gut microbiota following immunization and subsequent exposure to wild-type Salmonella enterica serovar Typhi in a human challenge mode...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1128/mbio.00686-18

Authors


More from this funder
Name:
National Institutes of Health
Grant:
U19AI-082655to M.B.S
R01AI-036525
More from this funder
Name:
Wellcome Trust
Grant:
092661 Milestone
Publisher:
American Society for Microbiology
Journal:
mBio More from this journal
Volume:
9
Issue:
3
Pages:
e00686-18
Publication date:
2018-05-08
Acceptance date:
2018-04-05
DOI:
ISSN:
2150-7511
Pmid:
29739901
Language:
English
Keywords:
Pubs id:
pubs:847413
UUID:
uuid:62b771d5-8869-439d-a69f-348d8bcdc7ba
Local pid:
pubs:847413
Source identifiers:
847413
Deposit date:
2018-05-12

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