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A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

Abstract:

Background: Owing to its role in cancer, the phosphoinositide 3-kinase (PI3K)/Akt pathway is an attractive target for therapeutic intervention. We previously reported that the inhibition of Akt by inositol 1,3,4,5,6- pentakisphosphate (InsP5) results in anti-tumour properties. To further develop this compound we modified its structure to obtain more potent inhibitors of the PI3K/Akt pathway.Methods: Cell proliferation/survival was determined by cell counting, sulphorhodamine or acridine orang...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/sj.bjc.6605408

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Department:
Default/Not Applicable
Role:
Author
Publisher:
Nature Publishing Group
Journal:
British Journal of Cancer More from this journal
Volume:
102
Pages:
104–114
Publication date:
2010-01-05
Acceptance date:
2009-10-08
DOI:
ISSN:
0007-0920 and 1532-1827
Pmid:
20051961

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