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Thesis

A new detergent-free approach to solubilize membrane proteins to maintain their native environment

Abstract:

Biophysical characterisation of membrane receptors in their native environment is essential for drug development, as lipid removal may affect conformational freedom and ligand binding. Membrane proteins are commonly solubilised with detergent for structural and functional studies, although the resulting micelles may be polydisperse, prone to aggregation and occlude of the binding site. Recently a hydrolysed copolymer of styrene and maleic acid (SMA) has been shown to be highly effect...

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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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