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Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease

Abstract:
Background Chlamydia trachomatis (Ct) plasmid has been shown to encode genes essential for infection. We evaluated the population structure of Ct using whole-genome sequence data (WGS). In particular, the relationship between the Ct genome, plasmid and disease was investigated. Results WGS data from 157 Ct isolates deposited in the Chlamydiales pubMLST database (http://pubMLST.org/chlamydiales/) were annotated with 902 genes including the core and accessory ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12864-018-4522-3

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
Hertford College
Role:
Author
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Funding agency for:
Jolley, K
Grant:
Biomedical Resource Grant (104992
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Funding agency for:
Maiden, M
Grant:
H2RXJo00
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Funding agency for:
Maiden, M
Grant:
H2RXJo00
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Funding agency for:
Harrison, O
Grant:
H2RXJo00
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Funding agency for:
Harrison, O
Grant:
H2RXJo00
Publisher:
BioMed Central Publisher's website
Journal:
BMC Genomics Journal website
Volume:
19
Article number:
130
Publication date:
2018-02-09
Acceptance date:
2018-01-31
DOI:
ISSN:
1471-2164
Source identifiers:
824697
Keywords:
Pubs id:
pubs:824697
UUID:
uuid:62ac85fc-4456-4086-a620-e0a15c8bef3c
Local pid:
pubs:824697
Deposit date:
2018-02-15

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