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The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Abstract:

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-study integrating TWAS, GWAS, and eQTL analyses. We find the majority of P. falciparum parasites are transcriptomically converged within each geographic site with two broader physiological profiles a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-07588-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-8060-6771
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Grant:
106698/B/14/Z milestone
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
5158
Publication date:
2018-12-04
Acceptance date:
2018-11-02
DOI:
EISSN:
2041-1723
Pmid:
30514877
Source identifiers:
950956
Language:
English
Keywords:
Pubs id:
pubs:950956
UUID:
uuid:62a01ea2-b268-46a2-9869-f9e993579ab4
Local pid:
pubs:950956
Deposit date:
2018-12-13

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