- Abstract:
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The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-study integrating TWAS, GWAS, and eQTL analyses. We find the majority of P. falciparum parasites are transcriptomically converged within each geographic site with two broader physiological profiles a...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
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(pdf, 4.3MB)
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- Publisher copy:
- 10.1038/s41467-018-07588-x
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Pages:
- Article: 5158
- Publication date:
- 2018-12-04
- Acceptance date:
- 2018-11-02
- DOI:
- EISSN:
-
2041-1723
- Pubs id:
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pubs:950956
- URN:
-
uri:62a01ea2-b268-46a2-9869-f9e993579ab4
- UUID:
-
uuid:62a01ea2-b268-46a2-9869-f9e993579ab4
- Local pid:
- pubs:950956
- Language:
- English
- Keywords:
- Copyright holder:
- Zhu et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
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