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The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Abstract:

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-study integrating TWAS, GWAS, and eQTL analyses. We find the majority of P. falciparum parasites are transcriptomically converged within each geographic site with two broader physiological profiles a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-07588-x

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-8060-6771
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
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Grant:
106698/Z/14/A milestone
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 5158
Publication date:
2018-12-04
Acceptance date:
2018-11-02
DOI:
EISSN:
2041-1723
Pubs id:
pubs:950956
URN:
uri:62a01ea2-b268-46a2-9869-f9e993579ab4
UUID:
uuid:62a01ea2-b268-46a2-9869-f9e993579ab4
Local pid:
pubs:950956

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