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A self-organising biomimetic collagen/nano-hydroxyapatite-glycosaminoglycan scaffold for spinal fusion

Abstract:

The use of spinal fusion surgery as a treatment for degenerative spinal conditions and chronic back pain is increasing. However, this technique requires use of a bone grafting material to fuse the vertebrae, traditionally autologous bone, which consists of an optimal combination of osteogenic cell precursors, extracellular matrix proteins and mineral components. To date, this remains the ‘gold standard’ material but its supply is limited and is associated with a number of clinical and ethical...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s10853-017-1229-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Grant:
Dunhill Trust Research Fellowship
Publisher:
Springer US Publisher's website
Journal:
Journal of Materials Science Journal website
Volume:
52
Issue:
21
Pages:
12574-12592
Publication date:
2017-07-28
DOI:
EISSN:
1573-4803
ISSN:
0022-2461
Pubs id:
pubs:713576
URN:
uri:62a002c4-509e-498c-b50d-22dc97fe0b2c
UUID:
uuid:62a002c4-509e-498c-b50d-22dc97fe0b2c
Local pid:
pubs:713576
Paper number:
21

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