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IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.

Abstract:

IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms involved remain to be resolved. Using primary human macrophages, we found that IL-10 inhibits selected inflammatory genes, primarily at a level of transcription. At the TNF gene, this occurs not through an inhibition of RNA polymerase II (Pol II) recruitment and transcription initiation but through a mechanism targeting the stimulation of transcription elongation by cyclin-dependent kinase (CDK) ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20100414

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
207
Issue:
10
Pages:
2081-2088
Publication date:
2010-09-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007

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