- Abstract:
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Diet-induced obesity is associated with increased adipose tissue activated macrophages. Yet, how macrophages integrate fatty acid (FA) signals remains unclear. We previously demonstrated that Fyn deficiency (fynKO) protects against high fat diet-induced adipose tissue macrophage accumulation. Herein, we show that inflammatory markers and reactive oxygen species are not induced in fynKO bone marrow-derived macrophages exposed to the saturated FA palmitate, suggesting that Fyn regulates macroph...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0MB)
-
- Publisher copy:
- 10.18632/oncotarget.21258
-
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- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 8
- Issue:
- 49
- Pages:
- 86634-86645
- Publication date:
- 2017-09-05
- Acceptance date:
- 2017-07-19
- DOI:
- EISSN:
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1949-2553
- ISSN:
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1949-2553
- Pubs id:
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pubs:738873
- URN:
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uri:62951b73-c2bb-46c7-94d6-5f24fbde099b
- UUID:
-
uuid:62951b73-c2bb-46c7-94d6-5f24fbde099b
- Local pid:
- pubs:738873
- Language:
- English
- Keywords:
- Copyright holder:
- Vatish et al
- Copyright date:
- 2017
- Notes:
- Tarabra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages.
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University of Warwick
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