Journal article
Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages.
- Abstract:
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Diet-induced obesity is associated with increased adipose tissue activated macrophages. Yet, how macrophages integrate fatty acid (FA) signals remains unclear. We previously demonstrated that Fyn deficiency (fynKO) protects against high fat diet-induced adipose tissue macrophage accumulation. Herein, we show that inflammatory markers and reactive oxygen species are not induced in fynKO bone marrow-derived macrophages exposed to the saturated FA palmitate, suggesting that Fyn regulates macroph...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.18632/oncotarget.21258
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Authors
Funding
University of Warwick
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Bibliographic Details
- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 8
- Issue:
- 49
- Pages:
- 86634-86645
- Publication date:
- 2017-09-01
- Acceptance date:
- 2017-07-19
- DOI:
- EISSN:
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1949-2553
- ISSN:
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1949-2553
- Pmid:
-
29156823
- Source identifiers:
-
738873
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:738873
- UUID:
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uuid:62951b73-c2bb-46c7-94d6-5f24fbde099b
- Local pid:
- pubs:738873
- Deposit date:
- 2018-03-21
Terms of use
- Copyright holder:
- Vatish et al
- Copyright date:
- 2017
- Notes:
- Tarabra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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