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Journal article

Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages.

Abstract:

Diet-induced obesity is associated with increased adipose tissue activated macrophages. Yet, how macrophages integrate fatty acid (FA) signals remains unclear. We previously demonstrated that Fyn deficiency (fynKO) protects against high fat diet-induced adipose tissue macrophage accumulation. Herein, we show that inflammatory markers and reactive oxygen species are not induced in fynKO bone marrow-derived macrophages exposed to the saturated FA palmitate, suggesting that Fyn regulates macroph...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.18632/oncotarget.21258

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
ORCID:
0000-0002-6012-2574
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University of Warwick More from this funder
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
8
Issue:
49
Pages:
86634-86645
Publication date:
2017-09-05
Acceptance date:
2017-07-19
DOI:
EISSN:
1949-2553
ISSN:
1949-2553
Pubs id:
pubs:738873
URN:
uri:62951b73-c2bb-46c7-94d6-5f24fbde099b
UUID:
uuid:62951b73-c2bb-46c7-94d6-5f24fbde099b
Local pid:
pubs:738873

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