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Journal article

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

Abstract:

Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. Despite their largely conserved fold, surface properties of PTPs are strikingly diverse. A potential secondary substrate-binding pocket is frequently found in phosphatases, and this has implications...

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Journal:
Cell More from this journal
Volume:
136
Issue:
2
Pages:
352-363
Publication date:
2009-01-01
ISSN:
1097-4172
Language:
English
Subjects:
UUID:
uuid:6294ec51-d506-4c70-8a04-650899618a68
Local pid:
SGC:19167335
Deposit date:
2011-08-18

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