Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.

Journal article

Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point and multipoint nonparametric linkage analysis was performed. Regions were identified showing "suggestive" or stronger linkage with the disease on chromosomes 1p, 2q, 6p, 9q, 10q, 16q, and 19q. The M...

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Authors: Laval, S; Timms, A; Edwards, S; Bradbury, L; Brophy, S

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 68
• Issue: 4
• Pages: 918-926
• Publication date: 2001-04-01
• DOI: 10.1086/319509
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Spondylitis, Ankylosing; Statistics, Nonparametric; Genotype; Chromosomes, Human; Cohort Studies; Humans; Genetic Predisposition to Disease; Genome, Human; Software; Female; Major Histocompatibility Complex; Chromosome Mapping; Matched-Pair Analysis; Nuclear Family; Male; Lod Score; Genetic Testing