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Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.

Abstract:

Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point and multipoint nonparametric linkage analysis was performed. Regions were identified showing "suggestive" or stronger linkage with the disease on chromosomes 1p, 2q, 6p, 9q, 10q, 16q, and 19q. The M...

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Publication status:
Published

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Publisher copy:
10.1086/319509

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Journal:
American journal of human genetics More from this journal
Volume:
68
Issue:
4
Pages:
918-926
Publication date:
2001-04-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Language:
English
Keywords:
Pubs id:
pubs:108913
UUID:
uuid:6287d62c-d28a-4b4d-a80e-f9869b595e1b
Local pid:
pubs:108913
Source identifiers:
108913
Deposit date:
2013-11-16

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