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Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.

Abstract:

BACKGROUND: Integrin-linked kinase (ILK) and its associated complex of proteins are involved in many cellular activation processes, including cell adhesion and integrin signaling. We have previously demonstrated that mice with induced platelet ILK deficiency show reduced platelet activation and aggregation, but only a minor bleeding defect. Here, we explore this apparent disparity between the cellular and hemostatic phenotypes. METHODS: The impact of ILK inhibition on integrin αII b β3 activa...

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Publication status:
Published

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Publisher copy:
10.1111/jth.12620

Authors


Publisher:
Blackwell Publishing Ltd
Journal:
Journal of thrombosis and haemostasis : JTH More from this journal
Volume:
12
Issue:
8
Pages:
1342-1352
Publication date:
2014-08-01
DOI:
EISSN:
1538-7836
ISSN:
1538-7933
Language:
English
Keywords:
Pubs id:
pubs:469586
UUID:
uuid:628140fb-44bb-4b39-9397-94f34079bc1b
Local pid:
pubs:469586
Source identifiers:
469586
Deposit date:
2014-06-30

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