Journal article icon

Journal article

The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.

Abstract:

For a proper development of the placenta, maternal NK cells should not attack the fetal extravillous cytotrophoblast cells. This inhibition of maternal NK cells is partially mediated via the nonclassical MHC class I molecule HLA-G. Recently, we demonstrated that HLA-G forms disulfide-linked high molecular complexes on the surface of transfected cells. In the present study, we demonstrate that HLA-G must associate with beta(2)m for its interaction with CD85J/leukocyte Ig-like receptor-1 (LIR-1...

Expand abstract

Actions


Access Document


Publisher copy:
10.4049/jimmunol.175.8.4866

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
8
Pages:
4866-4874
Publication date:
2005-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:627c7aea-1ee5-46d3-a568-d921a4a53aeb
Source identifiers:
482811
Local pid:
pubs:482811

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP