Killer-cell immunoglobulin like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on Natural Killer (NK) cells, which have dual roles: (i) in fighting infection and (ii) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure su...Expand abstract
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Copyright © 2016 The Authors.
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Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution
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