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Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution

Abstract:

Killer-cell immunoglobulin like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on Natural Killer (NK) cells, which have dual roles: (i) in fighting infection and (ii) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure su...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00251-016-0935-9

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Funding agency for:
Gupta, S
Grant:
DIVERSITY
More from this funder
Funding agency for:
Penman, B
Grant:
096063/Z/11/Z
More from this funder
Funding agency for:
Gupta, S
Grant:
DIVERSITY
More from this funder
Funding agency for:
Penman, B
Grant:
096063/Z/11/Z
Publisher:
Springer Verlag Publisher's website
Journal:
Immunogenetics Journal website
Volume:
68
Issue:
10
Pages:
755–764
Publication date:
2016-01-01
Acceptance date:
2016-06-24
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
Source identifiers:
634664
Keywords:
Pubs id:
pubs:634664
UUID:
uuid:62711c43-3912-40f1-98c8-6155b726259a
Local pid:
pubs:634664
Deposit date:
2016-07-20

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