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Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution

Abstract:

Killer-cell immunoglobulin like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on Natural Killer (NK) cells, which have dual roles: (i) in fighting infection and (ii) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure su...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00251-016-0935-9

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Funding agency for:
Penman, BS
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Funding agency for:
Penman, BS
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Funding agency for:
Gupta, S
Publisher:
Springer Verlag Publisher's website
Journal:
Immunogenetics Journal website
Volume:
68
Issue:
10
Pages:
755–764
Publication date:
2016-01-01
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:62711c43-3912-40f1-98c8-6155b726259a
Source identifiers:
634664
Local pid:
pubs:634664
Paper number:
10

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