Journal article
Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution
- Abstract:
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Killer-cell immunoglobulin like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on Natural Killer (NK) cells, which have dual roles: (i) in fighting infection and (ii) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure su...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1007/s00251-016-0935-9
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Verlag Publisher's website
- Journal:
- Immunogenetics Journal website
- Volume:
- 68
- Issue:
- 10
- Pages:
- 755–764
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-06-24
- DOI:
- EISSN:
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1432-1211
- ISSN:
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0093-7711
- Source identifiers:
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634664
Item Description
- Keywords:
- Pubs id:
-
pubs:634664
- UUID:
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uuid:62711c43-3912-40f1-98c8-6155b726259a
- Local pid:
- pubs:634664
- Deposit date:
- 2016-07-20
Terms of use
- Copyright holder:
- Penman et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Authors.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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