- Abstract:
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Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
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(pdf, 4.9MB)
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- Publisher copy:
- 10.1038/s41467-019-09976-3
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Pages:
- Article number: 2176
- Publication date:
- 2019-05-15
- Acceptance date:
- 2019-04-11
- DOI:
- EISSN:
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2041-1723
- Pubs id:
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pubs:923206
- URN:
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uri:6270a391-8c23-4e96-90ab-c25f4b470b57
- UUID:
-
uuid:6270a391-8c23-4e96-90ab-c25f4b470b57
- Local pid:
- pubs:923206
- Copyright holder:
- Lees et al.
- Copyright date:
- 2019
- Notes:
-
© The Author(s) 2019. Open Access This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Journal article
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
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