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Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Abstract:

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-019-09976-3

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Role:
Author
ORCID:
0000-0001-5360-1254
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Funding agency for:
Knight, JC
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article number: 2176
Publication date:
2019-05-15
Acceptance date:
2019-04-11
DOI:
EISSN:
2041-1723
Pubs id:
pubs:923206
URN:
uri:6270a391-8c23-4e96-90ab-c25f4b470b57
UUID:
uuid:6270a391-8c23-4e96-90ab-c25f4b470b57
Local pid:
pubs:923206

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