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Journal article

Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo.

Abstract:

A key challenge faced by promising antiviral drugs, such as iminosugars, is in vivo delivery to achieve effective levels of drug without toxicity. Four iminosugars, all deoxynojirimycin (DNJ) derivatives-N-butyl DNJ (NB-DNJ), N-nonyl DNJ, N-(9-methoxynonyl) DNJ, and N-(6'-[4″-azido-2″-nitrophenylamino]hexyl)-1-DNJ (NAP-DNJ)-potently inhibited both the percentage of cells infected with dengue virus and release of infectious virus from primary human monocyte-derived macrophages, demonstrating t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01554-12

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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More from this funder
Funding agency for:
Sayce, A
Grant:
Sant
erGraduateScholarship
More from this funder
Funding agency for:
Sayce, A
Grant:
erGraduateScholarship
Sant
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
56
Issue:
12
Pages:
6379-6386
Publication date:
2012-10-15
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
356210
Language:
English
Keywords:
Pubs id:
pubs:356210
UUID:
uuid:626f233b-7dae-4020-aa8b-f83bf1e2484e
Local pid:
pubs:356210
Deposit date:
2013-11-16

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