Journal article
Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo.
- Abstract:
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A key challenge faced by promising antiviral drugs, such as iminosugars, is in vivo delivery to achieve effective levels of drug without toxicity. Four iminosugars, all deoxynojirimycin (DNJ) derivatives-N-butyl DNJ (NB-DNJ), N-nonyl DNJ, N-(9-methoxynonyl) DNJ, and N-(6'-[4″-azido-2″-nitrophenylamino]hexyl)-1-DNJ (NAP-DNJ)-potently inhibited both the percentage of cells infected with dengue virus and release of infectious virus from primary human monocyte-derived macrophages, demonstrating t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.0MB)
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(Version of record, pdf, 217.5KB)
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- Publisher copy:
- 10.1128/aac.01554-12
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Authors
Funding
+ Clarendon Fund
More from this funder
Funding agency for:
Sayce, A
Grant:
Sant
erGraduateScholarship
+ Pembroke College, Oxford
More from this funder
Funding agency for:
Sayce, A
Grant:
erGraduateScholarship
Sant
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 56
- Issue:
- 12
- Pages:
- 6379-6386
- Publication date:
- 2012-10-15
- DOI:
- EISSN:
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1098-6596
- ISSN:
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0066-4804
- Source identifiers:
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356210
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:356210
- UUID:
-
uuid:626f233b-7dae-4020-aa8b-f83bf1e2484e
- Local pid:
- pubs:356210
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- American Society for Microbiology
- Copyright date:
- 2012
- Notes:
- Copyright © 2012, American Society for Microbiology. All Rights Reserved. This is the publisher's version of the article. The final version is available online from the American Society for Microbiology at: [10.1128/AAC.01554-12].
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