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DR5 knockout mice are compromised in radiation-induced apoptosis.

Abstract:

DR5 (also called TRAIL receptor 2 and KILLER) is an apoptosis-inducing membrane receptor for tumor necrosis factor-related apoptosis-inducing ligand (also called TRAIL and Apo2 ligand). DR5 is a transcriptional target of p53, and its overexpression induces cell death in vitro. However, the in vivo biology of DR5 has remained largely unexplored. To better understand the role of DR5 in development and in adult tissues, we have created a knockout mouse lacking DR5. This mouse is viable and devel...

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Publication status:
Published

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Authors


Finnberg, N More by this author
Gruber, JJ More by this author
Rudolph, D More by this author
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Journal:
Molecular and cellular biology
Volume:
25
Issue:
5
Pages:
2000-2013
Publication date:
2005-03-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:626b9e89-1ae9-4a69-9519-b47c638ac3a9
Source identifiers:
118236
Local pid:
pubs:118236

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