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Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.

Abstract:

Tregs play an important role in protecting the skin from autoimmune attack. However, the extent of Treg trafficking between the skin and draining lymph nodes (DLNs) is unknown. We set out to investigate this using mice engineered to express the photoconvertible fluorescence protein Kaede, which changes from green to red when exposed to violet light. By exposing the skin of Kaede-transgenic mice to violet light, we were able to label T cells in the periphery under physiological conditions with...

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Publication status:
Published

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Publisher copy:
10.1172/jci40926

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Journal:
The Journal of clinical investigation
Volume:
120
Issue:
3
Pages:
883-893
Publication date:
2010-03-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:626a04bb-64af-4ed1-84bc-de6ad49cc62c
Source identifiers:
51965
Local pid:
pubs:51965

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