Tregs play an important role in protecting the skin from autoimmune attack. However, the extent of Treg trafficking between the skin and draining lymph nodes (DLNs) is unknown. We set out to investigate this using mice engineered to express the photoconvertible fluorescence protein Kaede, which changes from green to red when exposed to violet light. By exposing the skin of Kaede-transgenic mice to violet light, we were able to label T cells in the periphery under physiological conditions with...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record