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Journal article

IgG-specific cell-based assay detects potentially pathogenic MuSK-Abs in seronegative MG

Abstract:

To increase the detection of MuSK-Abs using a CBA and test their pathogenicity.Sera from 69 MuSK-RIA-positive patients with myasthenia gravis (MG) (Definite MuSK-MG), 169 patients negative for MuSK-RIA and AChR-RIA (seronegative MG, SNMG), 35 healthy individuals (healthy controls, HCs), and 16 NMDA receptor-Ab-positive (NMDAR-Ab) disease controls were tested for binding to MuSK on a CBA using different secondary antibodies.Initially, in addition to 18% of SNMG sera, 11% of HC and 19% of NMDAR...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Watney Trust/MGA/NIHR
Funding agency for:
Huda, S
Grant:
G0601617
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Vincent, A
More from this funder
Name:
Muscular Dystrophy Campaign
Funding agency for:
Cossins, J
More from this funder
Name:
Medical Research Council
Funding agency for:
Cossins, J
Publisher:
Lippincott, Williams & Wilkins
Journal:
Neurology, Neuroimmunology & Neuroinflammation More from this journal
Volume:
4
Issue:
2
Pages:
1-9
Publication date:
2017-06-05
Acceptance date:
2017-04-06
DOI:
EISSN:
2332-7812
Pmid:
28626780
Language:
English
Keywords:
Pubs id:
pubs:702310
UUID:
uuid:6263547a-1e0b-48d2-adae-a063e2b3e02b
Local pid:
pubs:702310
Source identifiers:
702310
Deposit date:
2018-01-10

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