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Mapping the heparin-binding site on the 13-14F3 fragment of fibronectin.

Abstract:

Fibronectin, a multifunctional glycoprotein of the extracellular matrix, plays a major role in cell adhesion. Various studies have revealed that the human 13th and 14th fibronectin type III domains (labeled (13)F3 and (14)F3 here) contain a heparin-binding site. Mapping of the heparin-binding sites of (13-14)F3, (13)F3, and (14)F3 by NMR chemical shift perturbation, isothermal titration calorimetry, and molecular modeling show that (13)F3 provides the dominant heparin-binding site and that th...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m208956200

Authors


Sachchidanand More by this author
Staunton, D More by this author
Forster, MJ More by this author
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Journal:
The Journal of biological chemistry
Volume:
277
Issue:
52
Pages:
50629-50635
Publication date:
2002-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:625e43a7-4ebb-4616-86f1-b2ba964792c1
Source identifiers:
246385
Local pid:
pubs:246385

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