Similar rates of exponential decrease in serum concentrations of free prostate-specific antigen (PSA), PSA complexed to alpha-1-antichymotrypsin, and human glandular kallikrein 2 (hK2) in prostate cancer patients treated with GnRH-analogues.

Journal article

BACKGROUND: Our recently reported finding of rapid bi-exponential elimination of free prostate-specific antigen (PSA) after radical retropubic prostatectomy in patients with moderately elevated PSA levels, which contrasted a very slow, linear elimination of PSA complexed to alpha-1-antichymotrypsin (ACT), prompted us to study whether these elimination rates were applicable for patients selected for castration treatment with very high pretreatment concentrations of PSA in serum. In addition, s...

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Authors: Björk, T; Schalken, J; Wittjes, W; Ljungberg, B; Lilja, H

• Journal: Prostate
• Volume: 47
• Issue: 1
• Pages: 14-20
• Publication date: 2001-04-01
• DOI: 10.1002/pros.1042
• EISSN: 1097-0045
• ISSN: 0270-4137
• Language: English
• Keywords: Male; Aged; Humans; Prostatectomy; Aged, 80 and over; Predictive Value of Tests; Prostatic Neoplasms; Middle Aged; Prostate-Specific Antigen; alpha 1-Antichymotrypsin; Gonadotropin-Releasing Hormone; Tissue Kallikreins