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Journal article

The role of genetic instability in the pathogenesis and progression of urothelial carcinoma

Abstract:

Cancer appears to arise as a series of rate limiting steps, each of which represents the attainment of one cellular capability necessary for uncontrolled growth and invasion. As alterations in gene number or sequence can lead to the development of these cellular capabilities, the regulation of DNA fidelity is a vital homeostatic process. Mechanisms that disrupt DNA regulation lead to genomic instability and occur on two levels affecting either chromosomes (CIN; chromosomal instability) or ind...

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Publisher copy:
10.1016/j.euus.2005.09.003

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
EAU Update Series More from this journal
Volume:
3
Issue:
4
Pages:
180-188
Publication date:
2005-12-01
DOI:
ISSN:
1570-9124
Language:
English
Keywords:
Pubs id:
pubs:120945
UUID:
uuid:6258b1b8-de5d-4b5b-96b4-e3ef66c81063
Local pid:
pubs:120945
Source identifiers:
120945
Deposit date:
2013-02-20

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