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Computational models of amorphous ice for accurate simulation of cryo-EM images of biological samples

Abstract:

Simulations of cryo-electron microscopy (cryo-EM) images of biological samples can be used to produce test datasets to support the development of instrumentation, methods, and software, as well as to assess data acquisition and analysis strategies. To be useful, these simulations need to be based on physically realistic models which include large volumes of amorphous ice. The gold standard model for EM image simulation is a physical atom-based ice model produced using molecular dynamics simul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ultramic.2023.113882

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Publisher:
Elsevier
Journal:
Ultramicroscopy More from this journal
Volume:
256
Article number:
113882
Place of publication:
Netherlands
Publication date:
2023-11-04
Acceptance date:
2023-11-01
DOI:
EISSN:
1879-2723
ISSN:
0304-3991
Pmid:
37979542
Language:
English
Keywords:
Pubs id:
1569462
Local pid:
pubs:1569462
Deposit date:
2024-03-07

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