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Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

Abstract:

Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria parasite Plasmodium falciparum, this involves transcriptional switching among members of the var gene family, causing parasites with different antigenic and phenotypic characteristics to appear at different times within a population. Here we use a genome-wide approach to explore this process in vitro within a set of cloned parasite popul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1001306

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Name:
Wellcome Trust
Funding agency for:
Newbold, C
Grant:
082130/Z/07/Z
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Name:
Rhodes Trust
Funding agency for:
Serazin, A
More from this funder
Name:
Royal Society Wolfson Research
Funding agency for:
Gupta, S
More from this funder
Name:
Royal Society University Research
Funding agency for:
Recker, M
Publisher:
Public Library of Science
Journal:
PLoS pathogens More from this journal
Volume:
7
Issue:
3
Pages:
e1001306
Publication date:
2011-03-03
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Language:
English
Keywords:
UUID:
uuid:62551834-4faa-4176-a71b-36e85ea818b7
Local pid:
pubs:124373
Source identifiers:
124373
Deposit date:
2012-12-19

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