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Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naive CD4+ T cells via blood vessels and lymphatics.

Abstract:

The tumor microenvironment comprises newly formed blood and lymphatic vessels which shape the influx, retention and departure of lymphocytes within the tumor mass. Thus, by influencing the intratumoral composition of lymphocytes, these vessels affect the manner in which the adaptive immune system responds to the tumor, either promoting or impairing effective antitumor immunity. In our study, we utilized a mouse model of carcinogen-induced fibrosarcoma to examine the composition of tumor-infil...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijc.28556

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Publisher:
John Wiley and Sons Publisher's website
Journal:
International journal of cancer. Journal international du cancer Journal website
Volume:
134
Issue:
9
Pages:
2156-2167
Publication date:
2014-05-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Source identifiers:
459141

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