Journal article
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
- Abstract:
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Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased transcriptomics shows an upregulation of collagens in both zebrafish and mouse macrophages following heart injury. Adoptive transfer of macrophages, from either collagen-tagged zebrafish or adult m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 9.5MB)
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- Publisher copy:
- https://doi.org/10.1038/s41467-019-14263-2
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Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Article number:
- 600
- Publication date:
- 2020-01-30
- Acceptance date:
- 2019-12-27
- DOI:
- EISSN:
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2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:1080826
- UUID:
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uuid:624f14a4-9405-4e67-9e8d-3709bd2ed117
- Local pid:
- pubs:1080826
- Source identifiers:
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1080826
- Deposit date:
- 2020-01-06
Terms of use
- Copyright holder:
- Simões, FC et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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