Journal article icon

Journal article

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

Abstract:

BACKGROUND: MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.0050054

Authors


More from this funder
Name:
Broad Medical Research Program
Grant:
0032
More from this funder
Name:
Australian National Health and Medical Research Council
Grant:
235608
Publisher:
Public Library of Science
Journal:
PLoS Med More from this journal
Volume:
5
Issue:
3
Article number:
e54
Publication date:
2008-03-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP