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Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone.

Abstract:

The actions of benzodiazepines were studied on the responses to GABA of the fast coxal depressor (D(f)) motor neurone of the cockroach, Periplaneta americana. Ro5-4864, diazepam and clonazepam were investigated. Responses to GABA receptors were enhanced by both Ro5-4864 and diazepam, whereas clonazepam, a potent-positive allosteric modulator of human GABA(A) receptors, was ineffective on the native insect GABA receptors of the D(f) motor neurone. Thus, clear pharmacological differences exist ...

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Publisher copy:
10.1007/s10158-009-0091-0

Authors


Buckingham, SD More by this author
Higashino, Y More by this author
Sattelle, DB More by this author
Journal:
Invertebrate neuroscience : IN
Volume:
9
Issue:
2
Pages:
85-89
Publication date:
2009-11-05
DOI:
EISSN:
1439-1104
ISSN:
1354-2516
URN:
uuid:62472474-8e84-450c-8936-44295cd355bf
Source identifiers:
296924
Local pid:
pubs:296924

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