- Abstract:
-
The actions of benzodiazepines were studied on the responses to GABA of the fast coxal depressor (D(f)) motor neurone of the cockroach, Periplaneta americana. Ro5-4864, diazepam and clonazepam were investigated. Responses to GABA receptors were enhanced by both Ro5-4864 and diazepam, whereas clonazepam, a potent-positive allosteric modulator of human GABA(A) receptors, was ineffective on the native insect GABA receptors of the D(f) motor neurone. Thus, clear pharmacological differences exist ...
Expand abstract - Publisher copy:
- 10.1007/s10158-009-0091-0
-
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- Journal:
- Invertebrate neuroscience : IN
- Volume:
- 9
- Issue:
- 2
- Pages:
- 85-89
- Publication date:
- 2009-11-05
- DOI:
- EISSN:
-
1439-1104
- ISSN:
-
1354-2516
- URN:
-
uuid:62472474-8e84-450c-8936-44295cd355bf
- Source identifiers:
-
296924
- Local pid:
- pubs:296924
- Copyright date:
- 2009
Journal article
Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone.
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