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Investigation on cytoophidium function and filament-forming proteins

Abstract:

In 2010, three independent groups reported that cytidine-5'-triphosphate synthase could form a filamentous structure. The term "cytoophidium" was coined in recognition of its observed serpent-like structure in Drosophila cells. In the last seven years of study on cytoophidia, lots of models and hypotheses related to cytoophidia have been put forward. In 2014, three independent studies pointed out that the CTP synthase-based cytoophidium is a functionally inactive structure. These ...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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