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High activity Rhenium-186 HEDP with autologous peripheral blood stem cell rescue: a phase I study in progressive hormone refractory prostate cancer metastatic to bone.

Abstract:

We tested the feasibility and toxicity of high activities Rhenium-186 hydroxyethylidene diphosphonate, with peripheral blood stem cell rescue in patients with progressive hormone refractory prostate cancer metastatic to bone. Twenty-five patients received between 2500 and 5000 MBq of Rhenium-186 hydroxyethylidene diphosphonate followed 14 days later by the return of peripheral blood peripheral blood stem cells. Activity limiting toxicity was defined as grade III haematological toxicity, lasti...

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Publisher copy:
10.1038/sj.bjc.6600348

Authors


O'Sullivan, JM More by this author
McCready, VR More by this author
Norman, AR More by this author
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Journal:
British journal of cancer
Volume:
86
Issue:
11
Pages:
1715-1720
Publication date:
2002-06-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:623d05ff-82f8-4ded-a1ac-46b055255f64
Source identifiers:
281034
Local pid:
pubs:281034

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