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Resolving the prevalence of somatic transposition in Drosophila

Abstract:

Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline. To understand the impact of transposition in somatic cells it is essential to reliably measure the frequency and map locations of new insertions. Here we identified thousands of putative somatic transposon insertions in neurons from individual Drosophila melanogaster using whole-genome sequencing. However, the number of de novo insertions did not...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.28297

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Waddell, S
Grant:
200846/Z/16/Z
More from this funder
Funding agency for:
Waddell, S
Grant:
200846/Z/16/Z
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Article number:
e28297
Publication date:
2017-07-25
Acceptance date:
2017-07-21
DOI:
ISSN:
2050-084X
Language:
English
Keywords:
Pubs id:
pubs:709608
UUID:
uuid:623616e1-4ad6-42db-a633-a44236569853
Local pid:
pubs:709608
Source identifiers:
709608
Deposit date:
2017-08-11

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