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Journal article

Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node.

Abstract:

Na+-Ca2+ exchange (NCX) current has been suggested to play a role in cardiac pacemaking, particularly in association with Ca2+ release from the sarcoplasmic reticulum (SR) that occurs just before the action potential upstroke. The present experiments explore in more detail the contribution of NCX to pacemaking. Na+-Ca2+ exchange current was inhibited by rapid switch to low-Na+ solution (with Li+ replacing Na+) within the time course of a single cardiac cycle to avoid slow secondary effects. R...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
Journal:
The Journal of physiology
Volume:
571
Issue:
Pt 3
Pages:
639-649
Publication date:
2006-03-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:62344255-d5bc-4cfc-aa71-05bd4ef13949
Source identifiers:
106408
Local pid:
pubs:106408

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