- Abstract:
-
Na+-Ca2+ exchange (NCX) current has been suggested to play a role in cardiac pacemaking, particularly in association with Ca2+ release from the sarcoplasmic reticulum (SR) that occurs just before the action potential upstroke. The present experiments explore in more detail the contribution of NCX to pacemaking. Na+-Ca2+ exchange current was inhibited by rapid switch to low-Na+ solution (with Li+ replacing Na+) within the time course of a single cardiac cycle to avoid slow secondary effects. R...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1113/jphysiol.2005.100305
-
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- Journal:
- The Journal of physiology
- Volume:
- 571
- Issue:
- Pt 3
- Pages:
- 639-649
- Publication date:
- 2006-03-05
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- URN:
-
uuid:62344255-d5bc-4cfc-aa71-05bd4ef13949
- Source identifiers:
-
106408
- Local pid:
- pubs:106408
- Copyright date:
- 2006
Journal article
Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node.
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