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New treatments compared to established treatments in randomized trials.

Abstract:

BACKGROUND: The proportion of proposed new treatments that are 'successful' is of ethical, scientific, and public importance. We investigated how often new, experimental treatments evaluated in randomized controlled trials (RCTs) are superior to established treatments. OBJECTIVES: Our main question was: "On average how often are new treatments more effective, equally effective or less effective than established treatments?" Additionally, we wanted to explain the observed results, i.e. whethe...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
Cochrane database of systematic reviews More from this journal
Volume:
10
Issue:
10
Pages:
MR000024
Publication date:
2012-01-01
DOI:
EISSN:
1469-493X
ISSN:
1469-493X
Language:
English
Keywords:
Pubs id:
pubs:368009
UUID:
uuid:6230696f-9c3d-4c4e-bfa5-0e8cbcc2e69c
Local pid:
pubs:368009
Source identifiers:
368009
Deposit date:
2013-11-16

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