Journal article
Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations
- Abstract:
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Background: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immune pathways have been shown to play roles in the pathogenesis of MDS, though the exact mechanisms of their activation in splicing mutant cases are not well understood.
Methods: RNA-seq data from SF3B1 mu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 6.1MB, Terms of use)
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- Publisher copy:
- 10.7554/elife.78136
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Funding
Bibliographic Details
- Publisher:
- eLife Sciences Publications
- Journal:
- eLife More from this journal
- Volume:
- 11
- Article number:
- e78136
- Publication date:
- 2022-08-30
- Acceptance date:
- 2022-07-12
- DOI:
- EISSN:
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2050-084X
- ISSN:
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2050-084X
- Pmid:
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36040792
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1278063
- Local pid:
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pubs:1278063
- Deposit date:
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2022-10-03
Terms of use
- Copyright holder:
- Choudhary. et al
- Copyright date:
- 2022
- Rights statement:
- © Choudhary, Pellagatti et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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