Journal article
High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility.
- Abstract:
-
The highly polymorphic nonclassical MHC class I chain-related (MIC) genes MICA and MICB encode stress inducible glycoproteins expressed on a variety of epithelial cells including intestinal cells. Interaction with the receptor NKG2D is likely to provide an important costimulatory signal for activation and proliferation of NK cells, activated macrophages and CD8 alphabeta and gammadelta T cells. Fifty-four MICA and 17 MICB alleles have been described to date. Although the functional significan...
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- Publication status:
- Published
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- Publisher copy:
- 10.1034/j.1399-0039.2002.600207.x
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Authors
Bibliographic Details
- Journal:
- Tissue antigens
- Volume:
- 60
- Issue:
- 2
- Pages:
- 164-179
- Publication date:
- 2002-08-01
- DOI:
- EISSN:
-
1399-0039
- ISSN:
-
0001-2815
- Source identifiers:
-
135473
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:135473
- UUID:
-
uuid:6223848c-4823-432b-90a0-4961531aaac0
- Local pid:
- pubs:135473
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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