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Journal article

High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility.

Abstract:

The highly polymorphic nonclassical MHC class I chain-related (MIC) genes MICA and MICB encode stress inducible glycoproteins expressed on a variety of epithelial cells including intestinal cells. Interaction with the receptor NKG2D is likely to provide an important costimulatory signal for activation and proliferation of NK cells, activated macrophages and CD8 alphabeta and gammadelta T cells. Fifty-four MICA and 17 MICB alleles have been described to date. Although the functional significan...

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Publication status:
Published

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Journal:
Tissue antigens
Volume:
60
Issue:
2
Pages:
164-179
Publication date:
2002-08-01
DOI:
EISSN:
1399-0039
ISSN:
0001-2815
Source identifiers:
135473

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