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The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Abstract:

BACKGROUND:Trials to assess the efficacy of the radical cure of Plasmodium vivax malaria with 8-aminoquinolines require that most post-treatment relapses are identified, but there is no consensus on the optimal duration of follow-up in either symptomatic or asymptomatic vivax malaria. The efficacy of a 14-day course of primaquine on the cumulative incidence of recurrent asymptomatic P. vivax infections detected by ultrasensitive quantitative PCR (uPCR) as a primary endpoint was assessed. METH...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-019-3091-5

Authors


More from this funder
Name:
Wellcome Trust
Grant:
101148/Z/13/Z
More from this funder
Name:
Bill and Melinda Gates Foundation
Grant:
OPP10811420
Journal:
Malaria Journal More from this journal
Volume:
19
Article number:
4
Publication date:
2020-01-03
Acceptance date:
2019-12-25
DOI:
EISSN:
1475-2875
Pmid:
31900172
Language:
English
Keywords:
Pubs id:
pubs:1080885
UUID:
uuid:6214534e-94e6-418b-9b97-8d4f6408551b
Local pid:
pubs:1080885
Source identifiers:
1080885
Deposit date:
2020-01-07

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