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Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is not a single disease entity, rather it describes a spectrum of liver conditions that range from fatty liver (steatosis) to more severe steatosis coupled with marked inflammation and fibrosis [non-alcoholic steatohepatitis (NASH)] to severe liver disease such as cirrhosis and possibly hepatocellular carcinoma. Obesity, notably abdominal obesity, is a common risk factor for NAFLD. The pathogenesis from steatosis to NASH is poorly understood, and the ...

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Publication status:
Published

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Publisher copy:
10.1111/liv.12523

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Liver international : official journal of the International Association for the Study of the Liver
Volume:
34
Issue:
7
Pages:
e180-e190
Publication date:
2014-08-05
DOI:
EISSN:
1478-3231
ISSN:
1478-3223
URN:
uuid:620d9845-38b4-476e-8c6c-364c9bacc348
Source identifiers:
457958
Local pid:
pubs:457958

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